- Prof Yuan-Xiong Deng received a B.S. degree in Pharmaceutical Science from Tongji Medical University, Wuhan, China in 1990 and an M.S. degree in Pharmacology from China Pharmaceutical University, Nanjing, China in 2003.
- He also received a Ph.D. degree in Pharmacokinetics from China Pharmaceutical University, Nanjing, China in 2007. Now Prof. Deng works in pharmacokinetics and pharmacology at Hunan Normal University, Changsha, China.
- In terms of pharmacokinetics, Prof Yuan-Xiong Deng mainly focuses on the pharmacokinetics of Traditional Chinese medicine and the pharmacokinetics in disease states such as diabetes mellitus, hyperlipemia, and atherosclerosis.
- For example, Prof Yuan-Xiong Deng has finished the pharmacokinetic research of baicalin in diabetic rats after oral administration of Traditional Chinese medicine Huanglian Jiedu decoction and the mechanism investigation of the pharmacokinetic change of baicalin.
- Moreover, the pharmacokinetics of wogonoside has been investigated after the diabetic rats were orally administrated with the extract of Huanglian Jiedu decoction and the extract of Scutellaria baicalensis, and then the mechanism resulting in the pharmacokinetic change of wogonoside has been investigated. And he has completed the pharmacokinetic investigation of crocin in hyperlipemia rats.
- For the pharmacological research, he mainly studies the pharmacological mechanism of Traditional Chinese medicine in treating diabetic hyperlipidemia and atherosclerosis. Especially, he currently concentrates on the investigation of the effects of Traditional Chinese medicine (TCM) on the intestinal microbiota of diabetes to explore the mechanism of TCM in the treatment of diabetes mellitus.
- For instance, Prof Yuan-Xiong Deng has finished the effects of the polysaccharide from Gynura divaricata（L.）DC. on the diabetic rats and completed the investigation of the effects of TCM Huanglian Jiedu decoction on the type 2 diabetic rats, and then explored the mechanism. Moreover, he has completed the investigation of the effects of crocin on atherosclerotic rats.
Academic/Professional Qualifications
- 1986.09-1990.06: B.Sc - Tongji Medical University, China.
- 2001.09-2004.06: MSc - China Pharmaceutical University, China.
- 2004.09-2007.06: PhD - China Pharmaceutical University, China.
- 2013.09-now: Professor - Hunan Normal University, China.
Professional/Consulting Activities
- Journal of Pharmacognosy and Phytotherapy (JPP) (Associate editor).
- Journal of Pharmacology & Pharmacotherapeutics (Advisory Board).
- Journal of Pharmaceutical Research and Health Care（Assitant Editor）.
- Journal of Pharmacy Research (Advisory Board).
- Chines society for the study of xenobiotics (Member).
- Chinese pharmacological society (Member).
Recent Representative Publications
- Li-Hua He, Jiao Li, Yuan-Xiong Deng*, Xiao-Jie Zhang, Rong Chen, Yuan Lv Comparative investigation on the pharmacokinetics of geniposide in type 2 diabetic and normal rats after oral administration of Fructus Gradeniae extract. J Chromatogr B Analyt Technol Biomed Life Sci. 2016, 1033:180-6. (SCI, IF 2.687)
- Meng-Yun He, Yuan-Xiong Deng*, Qun-Zhi Shi, Xiao-Jie Zhang, Yuan Lv. Comparative pharmacokinetic investigation on baicalin and wogonoside in type 2 diabetic and normal rats after oral administration of traditional Chinese medicine Huanglian Jiedu decoction. J Ethnopharmacol. 2014, 155(1):334-42. (SCI, IF 3.268)
- Xiao-Jie Zhang, Yuan-Xiong Deng*, Qun-Zhi Shi, Meng-Yun He, Bo Chen, Xi-Min Qiu. Hypolipidemic effect of the Chinese polyherbal Huanglian Jiedu decoction in type 2 diabetic rats and its possible mechanism. Phytomedicine. 2014, 21(5):615-23.
- Yuan-Xiong Deng, Xiao-Jie Zhang, Qun-Zhi Shi, Yu-Shuang Chen, Xi-Min Qiu, Bo Chen. Anti-hyperglycemic effects and mechanism of traditional Chinese medicine Huanglian Wan in streptozocin-induced diabetic rats. J Ethnopharmacol. 2012, 144(2):425-32. (SCI, IF 3.045)
- Yuan-Xiong Deng, Qun-Zhi Shi , Bo Chen, Xiao-Jie Zhang, Sheng-Zi Liu, Xi-Min Qiu. Comparative pharmacokinetics of baicalin in normal and the type 2 diabetic rats after oral administration of the Radix scutellariae extract. Fitoterapia 2012, 83(8):1435-1442. （SCI, IF 1.86）
- Yuan-xiong Deng, Yu-shuang Chen, Wei-ran Zhang, Bo Chen, Xi-min Qiu, Li-hua He, Ling-li Mu, Chang-hua Yang, Rong Chen. Polysaccharide from Gynura divaricata modulates the activities of intestinal disaccharidases in streptozotocin-induced diabetic rats. Br J Nutr,2011, 106(9):1323-9. (SCI, IF: 3.446)
- Sheng-zi Liu, Yuan-xiong Deng*, Bo Chen, Xiao-jie Zhang, Qun-zhi Shi, Xi-min Qiu. Antihyperglycemic effect of the traditional Chinese coptis -scutellaria herb couple and its main components in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2013, 145(2):490-8. (SCI, IF 3.045) (* Corresponding author)
- Yuan-Xiong Deng, Tong Lu, Lin Xie, Xiao-Dong Liu. High-performance liquid chromatographic method for the determination and pharmacokinetic studies on wogonoside in rat serum after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction. Biomed Chromatogr, 2006, 20(10):1098-102. (SCI)
- Deng Yuanxiong, Yang Changhua, Mu Lingli. Pharmacokinetic study on baicalin and wogonoside in diabetic rats in vivo after oral administrating Huanglian-Jiedu Decoction. Chin Tradit Herb Drugs, 2008, 39(2):227-231.
- Deng Yuan-xiong, Liu Li, Yu Sen, Xie Lin, Liu Xiao-dong. Simultaneous determination of geniposide and 4 flavonoids in the traditional Chinese medicinal preparation Huanglian Jiedu decoction by HPLC with programmed wavelength UV detection. Chinese Journal of Pharmaceutical Analysis. 2008, 28(2):182-186.
- Deng Yuanxiong, Liu Xiaodong, Liu Li, Chen Yushuang. Effects of Huanglian-Jiedu Decoction on small intestine disaccharidases in the diabetic rats. Chin Tradit Herb Drugs 2010，41(7):1127-1130.
- Deng Yuanxiong, He Lihua, Wan Siting, Chen Bo, Xie Qingji, Chen Yushuang, Zhao Bingqing, Chen Rong. Effects of Huanglian-Jiedu decoction on the formation of advanced glycation end products in vivo and in vitro. Chin Tradit Herb Drugs, 2011, 42(1):130-133.
- Li Liu, Yuan-xiong Deng, Yan Liang, et al. Increased Oral AUC of Baicalin in Streptozotocin-Induced Diabetic Rats due to the Increased Activity of Intestinal beta-Glucuronidase. Planta Med. 2010, 76(1):70-5. (SCI)
- Liu L, Deng Y, Yu S, Lu S, Xie L, Liu X. Berberine attenuates intestinal disaccharidases in streptozotocin-induced diabetic rats. Pharmazie. 2008, 63(5):384-8. (SCI)
- Sen Yu, Xiaoyan Pang, Yuanxiong Deng, Li Liu, Yan Liang, Xiaodong Liu, Lin Xie, Guangji Wang, Xinting Wang. A sensitive and specific liquid chromatography mass spectrometry methodfor simultaneous determination of berberine, palmatine, coptisine,epiberberine and jatrorrhizine from Coptidis Rhizoma in rat plasma. International Journal of Mass Spectrometry. 2007,268 :30–37. (SCI)
- Tong Lu, Jue Song, Fang Huang, Yuanxiong Deng, Lin Xie, Guangji Wang, Xiaodong Liu. Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats. J Ethnopharmacol 2007, 110:412–418. (SCI)
- Haiyan Liu, Xiao Xu, Zhihong Yang, Yuanxiong Deng, Xiaodong Liu, Lin Xie. Impaired function and expression of P-glycoprotein in blood–brain barrier of streptozotocin-induced diabetic rats. Brain Res. 2006, 1123(1):245-52. (SCI)
- Liu Li, Deng Yuanxiong, Zhang Dongmei, Pang Xiaoyan, Xie Lin, Liu Xiaodong. Effect of berberine on pharmacokinetics of baicalin in rats. Chinese Journal of Natural Medicines. 2007, 5(2)137-141.
