- Dr. Devaraj Venkatapura Chandrashekar is currently working as a Postdoctoral Research Scientist at Chapman University, focused on the development and optimization of drug metabolism studies and the characterization of cytochrome P-450 enzyme activities in subcellular fractions of various tissues like liver, kidney, and brain of rats by LC-MS/MS.
- Dr. Devaraj is also involved in characterizing the effect of alcoholic-liver injury on neurovascular and neuronal degeneration and its impact on the pathology of Alzheimer’s disease.
- Dr. Devaraj received his Ph.D. in Pharmaceutical Sciences from Jawaharlal Nehru Technological University Hyderabad (JNTUH), India in 2016, and was the recipient of the prestigious & competitive post-graduate fellowship from the All India Council of Technical Education (AICTE), New Delhi for the MS program.
- He Authored more than 30 publications in various peer-reviewed journals and also working as reviewer for peer indexed journals.
- His technical expertise lies in isolation, characterization, and structural elucidation of phytochemical constituents using various analytical techniques and evaluating their biological activity (invitro & in-vivo) for various pharmacological actions, in-vitro & in-vivo ADME screening, including high-throughput techniques in pharmacokinetics, bioanalysis, pharmacokinetic profiling across the species, and diseased state pharmacokinetic evaluation using suitable animal models.
Professional Experience
- Apr 2006 – Sep 2008: Aurigene Discovery Technologies Ltd., Research Associate.
- Aug-2009 – Apr 2010: Syngene International Ltd., Research Associate.
- Apr 2010 – June 2018: Jubilant Biosys Ltd., Senior Research Scientist.
- June 2018 – Present: Post-Doctoral Research Scholar/ Lab manager - Chapman University, School of Pharmacy, Orange, California, United States.
Education
- Apr 2016: Ph.D. in Pharmaceutical Sciences - J.N.T.U.H, Hyderabad, India.
- Apr 2006: MS, Pharmacology - R.G.U.H.S, Bangalore, India.
- Devaraj VC, Barent DuBois, Reza Mehvar. UPLC-MS/MS analysis of the Michaelis-Menten kinetics of CYP3Amediated midazolam 1'- and 4-hydroxylation in rat brain microsomes. J.Chromatogr.B. 2021; 1180: 122892, PMID: 34388602.
- Devaraj VC, Reza Mehvar. UPLC-MS/MS analysis of CYP1A-mediated ethoxyresorufin-O-deethylation activity in the rat kidney microsomes. J.Chromatogr.B. 2020;1153:122272, PMID: 32738524.
- Sreekanth D, Lavanya M, Devaraj VC§, Ravikanth B, Juluri Suresh, Saravanakumar D, Ziyu Li, Felix B, Norbert T, Mullangi R. High-throughput screening assay for the quantification of Cer d18:1/16:0, d18:1/24:0, d18:1/24:1, d18:1/18:0, d18:1/14:0, d18:1/20:0, and d18:1/22:0 in HepG2 cells using Rapid Fire mass spectrometry. Biomed Chromatogr. 2020; May;34(5): e4790., PMID: 28810079.
- Devaraj VC, Suresh PS, Dittakavi S, Hiremath RA, Bhamidipati RK, Richter W, Srinivas NR, Mullangi R. LCESI- MS/MS determination of 4-methylpyrazole in dog plasma and its application to a pharmacokinetic study in dogs. Biomed Chromatogr. 2017; DOI: 10.1002/bmc.4065, PMID: 28810079.
- Devaraj VC, Suresh PS, Kumar R, Bhamidipati RK, Richter W, Srinivas NR, Mullangi R. Sensitive LC-MS/MS Method for the Simultaneous Determination of Bendamustine and its Active Metabolite, γ-Hydroxybendamustine in Small Volume Mice and Dog Plasma and its Application to a Pharmacokinetic Study in Mice and Dogs. Drug Res (Stuttg); 2017; 67(9): 497–508. PMID: 28561238.
- NR Srinivas, W Richter, VC Devaraj, PS Suresh, RK Bhamidipati, R Mullangi. Infusion Rate Dependent Pharmacokinetics of Bendamustine with Altered formation of ƴ–hydroxybendamustine (M3) Metabolite following 30- and 60-min Infusion of Bendamustine in Rats. Drug Res (Stuttg); 2016; 66(7): 351–56. PMID: 27120083.
§: Equal contributing co-author.
Awards and Honors
- Recipient of post-graduate fellowship from All India Council of Technical Education (AICTE), New Delhi (2004-06). This is a very prestigious, competitive fellowship in India.
- Recognized and awarded as “Best Team player” by AbbVie pharmaceuticals for the significant contribution in the integrated discovery and FFS programs for the year 2011-12.
- Certificate of Appreciation”, 2006 by Aurigene. Received recognition for my valuable contribution towards the approval of “Early Candidate Development Proposal” for the DPP-4 project (Diabetic segment).
- Star Award 2015”, in appreciation of the Teamwork leading to fast-track for the research program of ocular targets.
- Recognized and awarded as “Most Engaged Associate-2012” by Jubilant Biosys, for the significant contribution and execution of various in-vivo and in-vitro ADME assays for various integrated discovery and FFS projects
- Secured ~90 percentile in GATE (2002, 2003) and was able to secure scholarship to continue post-graduation.
