Hu Richard

Research Papers (Peer-Reviewed):

• Hu, R, Ticku MK. Chronic flurazepam treatment produces decreased efficacy of the Benzodiazepine ligands and pentobarbital with GABA receptors in cortical neurons. J. Pharmacol. Exp. Ther. 270: 485-490, 1994.
• Hu R, Ticku MK. Chronic benzodiazepine agonist treatment produces functional uncoupling of GABA-benzodiazepine receptor complex in cortical neurons. Mol. Pharmacol. 45: 618-625, 1994.
• Hu R, Ticku MK. Development pattern of the GABA benzodiazepine receptor complex in primary cultures of cortical neurons. Dev. Brain Res. 80: 137-140, 1994.
• Hu R, Ticku MK. Chronic ethanol treatment upregulates the N-methyl-D-aspartate receptor function and binding in mammalian cortical neurons. Mol. Brain Res. 30: 347-356, 1995.
• Hu R, Follesa P, Ticku MK. Effect of chronic ethanol treatment on N-methyl-D-aspartate receptor function, binding and subunit mRNA levels in cortical neurons. Behavioral Pharmacology. 6(suppl. 1) 98, 1995.
• Hu R, Follesa P, Ticku MK. Chronic ethanol treatment selectively upregulated the N-methyl-D-aspartate receptor R2B subunit gene expression. Molecular Brain Res. 36: 211-218, 1996.
• Hu R, Ticku MK. Functional characterization of kindling-like model of ethanol withdrawal in cortical cultured neurons after chronic intermittent ethanol exposure. Brain Res. 767: 228-234, 1997.
• Harris K., Hu R, Schultz S, Arcasoy M, Forget B. The distal cytoplasmic domain of the Erythropoietin receptor induces granulocytic differentiation in 32D cells. Blood. 92: 1219-1224, 1998.
• Wang YL, Hu R, Pandol SJ. Ethanol feeding switches death pathway resulting in inhibition of apoptosis and promotion of necrosis in pancreas. Gastroenterology. 128 (suppl 2): M1635, 2005.
• Hu R, Pandol SJ. Pancreatic stellate cell NADPH oxidase system and its regulation by ethanol and growth factors. Gastroenterology. 128 (suppl 2): W1533, 2005.
• Hu R, Wang YL, Edderkaoui M, et al. Pancreatic stellate cell NADPH oxidase system and its role in mediating pancreatic stellate cell proliferation by PDGF. Pancreas. 31:446, 2005.
• Wang YL, Hu R, Smoot D, Gukovskaya AS, et al: Ethanol feeding alters death signaling in pancreas. Pancreas 32(4): 351-359, 2006.
• Hu R, Wang YL, Edderkaou M,, et al: Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells. Pancreatology. 7(4):332-40, 2007.
• El-Masry, M and Hu R: Cecal varices presenting as anemia: case report and review of the literature. Case Rep Gastroenterol. 2010, Dec 4, 4(3)524-7.
• Lu L, Feng M, Gu J, Xia Z, Zhang S, Duan Z, Hu R, et al. Restoration of intrahepatic regulatory T cells through MMP-9/13-dependent activation of TGF-β is critical for immune homeostasis following acute liver injury. J Mol Cell Biol. 5 (6): 369-379, 2013 .
• Suraweera D, Amin J, Baltayan A and Hu R. Brunner gland hamartoma as a rare cause of gastric outlet obstruction and a review of treatment strategies. Journal of Gastroenterology and Hepatology Research, 4(7): 1698-1701, 2015.
• Su D, Nie Y, Zhu A, Chen Z, Wu P, Zhang L, Luo M, Sun Q, Cai L, Lai Y, Xiao Z, Duan Z, Zheng S, Wu G, Hu R, et al. Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in animal models. Front Physiol, 7: 498, 2016.
• Yang Z, Liu Y, Qin L, Wu P, Xia Z, Luo M, Zeng Y, Tsukamoto H, Ju Z, Su D, Kang H, Xiao Z, Zheng S, Duan Z, Hu R, et al. Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases. Am J Pathol. Apr;187(4):781-97, 2017 19. Zhu A, Chen J, Wu P, Luo M, Zeng Y, Zheng H, Zhang L, Cheng Z, Sun Q, Li W, Duan Y, Su D, Xiao Z, Duan Z, Zheng S, Bei L, Zhang X, Ju Z, Hu R, et al. Cationic Polystyrene Resolves Nonalcoholic Steatohepatitis (NASH), Obesity, and Metabolic Disorders by Promoting Eubiosis of Gut Microbiota and Decreasing Endotoxemia. Diabetes. 66: 2137-43, 2017.
• Li Bai, Liu X, Zheng Q, Kong M, Zhang X, Hu R, et al. M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes. Sci Rep, 7: 10518-29, 2017.
• Luo M, Liu Y, Wu P, Luo DX, Sun Q, Zheng H, Hu R, Pandol SJ, Li QF, Han YP, ZengY. Alternation of Gut Microbiota in Patients with Pulmonary Tuberculosis. Front Physiol. 8: 822, 2017.
• Han Z, Yang Y, Hua M, Wu PF, Liu Y, Chen ZH, Li Zhang, Wei HC, Li Y, Luo M, Zeng YL Dong-Xia Luo, Jie Zhang, Feng M, Hu R, Pando SJl, Han YP. Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice. Front Physiol. 9: 1671, 2018.
• Wu P, Zhang R, Luo M, Zhang T, Pan L, Xu S, Pan L, Ren F, Ji C, Hu R, Noureddin M, Pandol SJ, Han YP. Liver Injury Impaired 25-Hydroxylation of Vitamin D Suppresses Intestinal Paneth Cell Defensins, Leading to Gut Dysbiosis and Liver Fibrogenesis. Am J Physiol Gastrointest Liver Physiol. 2020 Oct 21;319(6):G685-95. PMID: 33084400
• Zhang C, Yang H, Pan L, Zhao G, Zhang R, Zhang T, Xiao Z, Tong Y, Zhang Y, Hu R, Pandol SJ, Han YP. Hepatitis B Virus X Protein (HBx) Suppresses Transcription Factor EB (TFEB) Resulting in Stabilization of Integrin Beta 1 (ITGB1) in Hepatocellular Carcinoma Cells. Cancers (Basel). 2021 Mar 9;13(5):1181- PMID: 33803301 

Editorial

• Shahedi K, Pandol S and Hu, R. Oxidative Stress and Alcoholic Pancreatitis. Journal of Gastroenterology and Hepatology Research. 2(1): 335-342, 2013.
• Duminda B Suraweera, Ashley N Weeratunga, Robert W Hu, Stephen J Pandol and Richard Hu. Alcoholic Hepatitis- The pivotal role of Kupffer Cell. World J Gastrointest Pathophysiol 6(4):90-98, 2015.

Book Chapters

1. Hu R et al: Anatomy and physiology of the biliary tree.  In Barreto SG and Windsor JA, (eds): Surgical Diseases of the Pancreas and Biliary Tree, Springer, September 2018, p27-43.
2. Hu R et al: Physiology of the pancreas.  In Barreto SG and Windsor JA, (eds): Surgical Diseases of the Pancreas and Biliary Tree, Springer, September 2018, p45-63.

Honors and Awards

• 2016-present: Key clinical faculty UCLA GI fellowship program David Geffen School of Medicine at UCLA Los Angeles, California, United States.
• 1995: Young Investigator Award 8th Sardinian International Conference on Neuroscience Cagliari, Italy.
• 1998: The First Prize award, Research Day The University of Texas Health Science Center San Antonio, Texas , United States.