Experience
- 1981.09-1986.07: Undergraduate Student, Department of Clinical Medicine, Henan Medical University, China.
- 1986.08-1991.12: Resident Physician, Department of internal medicine, the first affiliated hospital, Henan University of Science and Technology, China.
- 1992.01-1993.08: Attending Physician, Department of internal medicine, the first affiliated hospital, Henan University of Science and Technology, China.
- 1993.09-1996.07: Postgraduate (Master) Student, Graduate School of Fudan University, China.
- 1996.08-2000.12: Attending Physician, Department of infectology, Shanghai tenth People's Hospital, Tongji University, China.
- 1998.10-2002.08: Deputy Director of the Department of infectiology, Shanghai tenth People's Hospital, China.
- 1998.10-2002.08: Deputy Director of the Teaching Section of Infectiology, the First Clinical school of Tongji University, China.
- 2001.01-2006.12: Associate Chief Physician, Department of infectology, Shanghai tenth People's Hospital; Department of Hepatology, Shanghai Public Health Clinical Center, Fudan University, China.
- 2002.09-2009.09: Deputy director of the Department of Hepatology, Shanghai Public Health Clinical Center, Fudan University, China.
- 2002.09-2009.09: Director of the Teaching Section of Infectiology, the First Clinical school of Tongji University, China.
- 2007.01-present: Chief physician, Department of Hepatology; Department of the Hepatobiliary medicine, Shanghai Public Health Clinical Center, Fudan University, China.
- 2008.09-present: Co-director of the Teaching Module of Pathogenic Biology and Infectiology, Medical School of Tongji University, China.
- 2009.10-2018.09: Director of the Second Department of Hepatology, Shanghai Public Health Clinical Center, Fudan University, China.
- 2018.10-present: Director of Department of the Hepatobiliary medicine, Shanghai Public Health Clinical Center, Fudan University, China.
Specialties
Having extensive practice experience:
- Engaged in clinical practice in internal medicine, infectiology, and hepatobiliary medicine for 36 years.
- Medical expertise: The diagnosis and treatment for viral hepatitis, drug-induced liver injury, fatty liver disease, alcoholic liver disease, autoimmune hepatitis, primary and secondary biliary cholangitis, and primary and secondary sclerosing cholangitis.
- Outstanding medical expertise: The etiological diagnosis of cryptogenic liver damage, the condition assessment for chronic liver diseases, the early diagnosis of liver cirrhosis and the prediction of severe and critical liver diseases; and individualized treatment for chronic hepatitis B and its related liver cirrhosis, portal hypertension, and liver decompensation.
Having extensive teaching experience:
- Engaged in teaching practice in internal medicine, infectiology, and pathogenic biology and infectiology for 36 years.
- Presided over and completed 4 national-level medical education projects, and 2 Shanghai-level medical education projects.
Having extensive clinical study experience:
- Presided over and completed two medical guidance projects of Shanghai Municipal Science and Technology Commission, one key research project of Shanghai Municipal Health Commission and one Shanghai Municipal Hospital cutting-edge technology research project.
- Participated in one National "863" Project of China in the eleventh five-year plan; six National Major Science and Technology Projects of China in the eleventh five-year, twelfth five-year’ and thirteenth five-year plan.
- Participated in more than 20 international multi-center clinical trial projects.
Having good writing skills:
- Published more than 250 professional papers, including 19 SCI papers as the first and corresponding author.
- Published 10 books and textbooks as an author.
- Published 2 books as an editor-in-chief and an associate editor.
- Zhang ZQ*, Shi BS, Lu W, Huang D, Wang YB, Feng YL. Quantitative serum HBV markers in predicting phases of natural history of chronic HBV infection. J Virol Methods. 2021; 296: 114226.
- Ding R, Yang Z, Huang D, Wang Y, Li X, Zhou X, Yan L, Lu W, Zhang Z*. Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19. Int J Med Sci. 2021; 18(5): 1207-1215.
- Zhang Z*, Lu W, Zeng D, Huang D, Lin W, Yan L, Feng Y. Quantitative HBsAg versus HBV DNA in Predicting Significant Hepatitis Activity of HBeAg-Positive Chronic HBV Infection. J Clin Med. 2021; 10(23): 5617.
- Ding R, Zhou X, Huang D, Wang Y, Li X, Yan L, Lu W, Yang Z, Zhang Z*. Nomogram for predicting advanced liver fibrosis and cirrhosis in patients with chronic liver disease. BMC Gastroenterol. 2021; 21(1): 190.
- Yang Z, Ma X, Zhou X, Huang D, Wang Y, Li X, Lu W, Zhang Z*, Ding R. Predictive performance of eLIFT for liver inflammation and fibrosis in chronic liver diseases. Int J Med Sci. 2021; 18(15): 3599-3608.
- Ding R, Zheng J, Li N, Cheng Q, Zhu M, Wang Y, Zhou X, Zhang Z*, Shi G. DZNep, an inhibitor of the histone methyltransferase EZH2, suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 pathway. PeerJ. 2021; 9: e11374.
- Ding R, Zheng J, Huang D, Wang Y, Li X, Zhou X, Yan L, Lu W, Yang Z, Zhang Z*. INR-to-platelet ratio (INPR) as a novel noninvasive index for predicting liver fibrosis in chronic hepatitis B. Int J Med Sci. 2021; 18(5): 1159-1166.
- Ding R, Zhou X, Huang D, Wang Y, Li X, Yan L, Lu W, Yang Z, Zhang Z*. Predictive Performances of Blood Parameter Ratios for Liver Inflammation and Advanced Liver Fibrosis in Chronic Hepatitis B Infection. Biomed Res Int. 2021; 2021: 6644855.
- Ding R, Lu W, Zhou X, Huang D, Wang Y, Li X, Yan L, Lin W, Song S, Zhang Z*, Chen L. A Novel Non-invasive Model Based on GPR for the Prediction of Liver Fibrosis in Patients With Chronic Hepatitis B. Front Med (Lausanne). 2021; 8: 727706.
- Liu D, Xu T, Shi B, Lu W, Zheng Y, Feng Y, Yuan Z, Zhang X, Zhang Z*. Clinical relevance of the in situ assay for HBV DNA: a cross-sectional study in patients with chronic hepatitis B. J Clin Pathol. 2020; 73(12):813-818.
- Zhang ZQ*, Shi BS, Lu W, Liu DP, Huang D, Feng YL. Quantitative HBcrAg and HBcAb versus HBsAg and HBV DNA in predicting liver fibrosis levels of chronic hepatitis B patients. Gastroenterol Hepatol. 2020; 43(9): 526-536.
- Yin L, Zhang Y, Shi H, Feng Y, Zhang Z, Zhang L. Proteomic profiling of hepatic stellate cells in alcohol liver fibrosis reveals proteins involved in collagen production. Alcohol. 2020; 86:81-91.
- Zhang ZQ*, Shi BS, Lu W, Liu DP, Huang D, Feng YL. Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection. Can J Infect Dis Med Microbiol. 2019; 2019: 6545642.
- Li B, Zhang L, Zhang Z #, Yan G, Zhu L, Lu W, Yu H. A noninvasive indicator for the diagnosis of early hepatitis B virus-related liver fibrosis. Eur J Gastroenterol Hepatol. 2019; 31(2): 218-223.
- Zhang ZQ*, Wang YB, Lu W, Liu DP, Shi BS, Zhang XN, Huang D, Li XF, Zhou XL, Ding RR. Performance of Hepatitis B Core-Related Antigen Versus Hepatitis B Surface Antigen and Hepatitis B Virus DNA in Predicting HBeAg-positive and HBeAg-negative Chronic Hepatitis. Ann Lab Med. 2019; 39(1):67-75.
- Li J, Dong XQ, Wu Z, Ma AL, Xie SB, Zhang XQ, Zhang ZQ, Zhang DZ, Zhao WF, Zhang G, Cheng J, Xie Q, Li J, Zou ZQ, Liu YX, Wang GQ, Zhao H; China Hepatitis B Related Fibrosis Assessment Research Group. Unsatisfying antiviral therapeutic effect in patients with mother-to-child transmissed chronic hepatitis B virus infection: a prospective multi-center clinical study. Chin Med J (Engl). 2019; 132(22): 2647-2656.
- Zhang Z*, Ding R, Lu W, Yang Z, Wang Y, Zhou X, Huang D, Li X, Feng Y. Performance evaluation of HBsAg by Lumipulse HBsAg-HQ: The agreement with HBsAg by Architect HBsAg-QT and the effectiveness in predicting liver tissue pathological states of chronic hepatitis B patients. Adv Clin Exp Med. 2018; 27(8): 1045-1054.
- Liu H, Li F, Zhang X, Yu J, Wang J, Jia J, Yu X, Shen Z, Yuan Z, Zhang X, Zhang Z, Zhang X, Lu L, Li H, Lu M, Zhang J. Differentially Expressed Intrahepatic Genes Contribute to Control of Hepatitis B Virus Replication in the Inactive Carrier Phase. J Infect Dis. 2018; 217(7): 1044-1054.
- Zhang ZQ*, Zhang XN, Lu W, Wang YB, Weng QC, Feng YL. Distinct patterns of serum hepatitis B core-related antigen during the natural history of chronic hepatitis B. BMC Gastroenterol. 2017; 17(1):140.
- Zhou W, Ma Y, Zhang J, Hu J, Zhang M, Wang Y, Li Y, Wu L, Pan Y, Zhang Y, Zhang X, Zhang X, Zhang Z, Zhang J, Li H, Lu L, Jin L, Wang J, Yuan Z, Liu J. Predictive model for inflammation grades of chronic hepatitis B: Large-scale analysis of clinical parameters and gene expressions. Liver Int. 2017; 37(11): 1632-1641.
- Yang FQ, Rao GR, Wang GQ, Li YQ, Xie Y, Zhang ZQ, Deng CL, Mao Q, Li J, Zhao W, Wang MR, Han T, Chen SJ, Pan C, Tan DM, Shang J, Zhang MX, Zhang YX, Yang JM, Chen GM. Phase IIb trial of in vivo electroporation mediated dual-plasmid hepatitis B virus DNA vaccine in chronic hepatitis B patients under lamivudine therapy. World J Gastroenterol. 2017; 23(2):306-317.
- Wang M, Gong Q, Zhang J, Chen L, Zhang Z, Lu L, Yu D, Han Y, Zhang D, Chen P, Zhang X, Yuan Z, Huang J, Zhang X. Characterization of gene expression profiles in HBV-related liver fibrosis patients and identification of ITGBL1 as a key regulator of fibrogenesis. Sci Rep. 2017; 7: 43446.
- Jia XF, Lu W, Yin L, Yuan ZH, Zhang LJ, Zhang ZQ. [Plasma proteome analysis of chronic hepatitis B patients with different stages of liver fibrosis]. Zhonghua Gan Zang Bing Za Zhi. 2012; 20(9): 659-63 [In Chinese].
- Li J, Zhang X, Chen L, Zhang Z, Zhang J, Wang W, Wu M, Shi B, Zhang X, Kozlowski M, Hu Y, Yuan Z. Circulating miR-210 and miR-22 combined with ALT predict the virological response to interferon-alpha therapy of CHB patients. Sci Rep. 2017; 7(1): 15658.
- Gao Y, Li Y, Meng Q, Zhang Z, Zhao P, Shang Q, Li Y, Su M, Li T, Liu X, Zhuang H. Serum Hepatitis B Virus DNA, RNA, and HBsAg: Which Correlated Better with Intrahepatic Covalently Closed Circular DNA before and after Nucleos(t)ide Analogue Treatment? J Clin Microbiol. 2017; 55(10):2972-2982.
- Zhang X, Yue L, Zhang Z*, Yuan Z. Establishment of a fluorescent in situ hybridization assay for imaging hepatitis B virus nucleic acids in cell culture models. Emerg Microbes Infect. 2017; 6(11):e98.
- Zhang X, Lu W, Zheng Y, Wang W, Bai L, Chen L, Feng Y, Zhang Z*, Yuan Z. In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection. J Clin Invest. 2016; 126(3): 1079-92.
- Zhang ZQ*, Lu W, Wang YB, Weng QC, Zhang ZY, Yang ZQ, Feng YL. Measurement of the hepatitis B core-related antigen is valuable for predicting the pathological status of liver tissues in chronic hepatitis B patients. J Virol Methods. 2016; 235: 92-98.
- Chen C, Wu M, Zhang W, Lu W, Zhang M, Zhang Z, Zhang X, Yuan Z. MicroRNA-939 restricts Hepatitis B virus by targeting Jmjd3-mediated and C/EBPα-coordinated chromatin remodeling. Sci Rep. 2016; 6:35974.
- Zhang X, Zhang Z, Dai F, Shi B, Chen L, Zhang X, Zang G, Zhang J, Chen X, Qian F, Hu Y, Yuan Z. Comparison of circulating, hepatocyte specific messenger RNA and microRNA as biomarkers for chronic hepatitis B and C. PLoS One. 2014; 9(3): e92112.
- Chen J, Wu M, Zhang X, Zhang W, Zhang Z, Chen L, He J, Zheng Y, Chen C, Wang F, Hu Y, Zhou X, Wang C, Xu Y, Lu M, Yuan Z. Hepatitis B virus polymerase impairs interferon-α-induced STA T activation through inhibition of importin-α5 and protein kinase C-δ. Hepatology. 2013; 57(2): 470-82.
- Shi B, Ren G, Hu Y, Wang S, Zhang Z, Yuan Z. HBsAg inhibits IFN-α production in plasmacytoid dendritic cells through TNF-α and IL-10 induction in monocytes. PLoS One. 2012; 7(9): e44900.
- Zhang X, Chen C, Wu M, Chen L, Zhang J, Zhang X, Zhang Z, Wu J, Wang J, Chen X, Huang T, Chen L, Yuan Z. Plasma microRNA profile as a predictor of early virological response to interferon treatment in chronic hepatitis B patients. Antivir Ther. 2012; 17(7): 1243-53.
- Zhang L, Jia X, Feng Y, Peng X, Zhang Z, Zhou W, Zhang Z, Ma F, Liu X, Zheng Y, Yang P, Yuan Z. Plasma membrane proteome analysis of the early effect of alcohol on liver: implications for alcoholic liver disease. Acta Biochim Biophys Sin (Shanghai). 2011; 43(1):19-29.
- Zhang L, Peng X, Zhang Z, Feng Y, Jia X, Shi Y, Yang H, Zhang Z, Zhang X, Liu L, Yin L, Yuan Z. Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis. J Cell Biochem. 2010; 110(1): 219-28.
- Xu Y, Hu Y, Shi B, Zhang X, Wang J, Zhang Z, Shen F, Zhang Q, Sun S, Yuan Z. HBsAg inhibits TLR9-mediated activation and IFN-alpha production in plasmacytoid dendritic cells. Mol Immunol. 2009; 46(13): 2640-6.
- Chen Z, Cheng Y, Xu Y, Liao J, Zhang X, Hu Y, Zhang Q, Wang J, Zhang Z, Shen F, Yuan Z. Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients. Clin Immunol. 2008; 128(3):400-8.
Note: *corresponding or co-corresponding author, #co-first author.
