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Xudong Peng

Xudong Peng

Xudong Peng

M.D, M.S, Ph.D University of Washington, Department of Ophthalmology United States

BIOGRAPHY 6 PUBLICATIONS 56 ACCOMPLISHMENTS 3

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Professional Experience and Education

  • 07/2021-07/2023: Postdoc Scholar, Ophthalmology - University of Washington.
  • 07/2018-07/2021: Resident Doctor, Ophthalmology - The Affiliated Hospital of Qingdao University.
  • 10/2016-01/2018: Exchange student, Ophthalmology - Medical school of Wayne State University.
  • 09/2015-06/2018: Ph.D, Ophthalmology - Qingdao University Medical College.
  • 09/2012-06/2015: M.S, Ophthalmology - Qingdao University Medical College.
  • 09/2007-06/2012: M.D, Medicine - Ji Ning Medical College.
  • X Gao, G Zhao, C Li, J Lin, N Jiang, Q Wang, L Hu, Q Xu, X Peng, K He. LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis. International immunopharmacology 2016, 40, 392-399.
  • N Jiang, G Zhao, J Lin, L Hu, C Che, C Li, Q Wang, Q Xu, X Peng. Indoleamine 2,3-Dioxygenase Is Involved in the Inflammation Response of Corneal Epithelial Cells to Aspergillus fumigatus Infections. PLoS One 2015,10 (9), e0137423.
  • L Gu, J Lin, Q Wang, C Li, X Peng, Y Fan, C Lu, H Lin, Y Niu, G Zhu. Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO‐1 signaling pathway. Immunology and cell biology 2020, 98 (3), 229-241.
  • XD Peng, GQ Zhao, J Lin, N Jiang, Q Xu, CC Zhu, JQ Qu, L Cong, H Li. Fungus induces the release of IL-8 in human corneal epithelial cells, via Dectin-1-mediated protein kinase C pathways. International journal of ophthalmology 2015, 8 (3), 441.
  • CC Zhu, GQ Zhao, J Lin, LT Hu, Q Xu, XD Peng, X Wang, S Qiu. Dectin-1 agonist curdlan modulates innate immunity to Aspergillus fumigatus in human corneal epithelial cells. International journal of ophthalmology 2015, 8 (4), 690.
  • K He, LH Yue, GQ Zhao, C Li, J Lin, N Jiang, Q Wang, Q Xu, XD Peng. The role of LOX-1 on innate immunity against Aspergillus keratitis in mice. International Journal of Ophthalmology 2016, 9 (9), 1245.
  • Y Fan, C Li, X Peng, N Jiang, L Hu, L Gu, G Zhu, G Zhao, J Lin. Perillaldehyde ameliorates Aspergillus fumigatus keratitis by activating the Nrf2/HO-1 signaling pathway and inhibiting dectin-1-mediated inflammation. Investigative Ophthalmology & Visual Science 2020, 61 (6), 51-51.
  • X Wu, G Zhao, J Lin, N Jiang, C Li, L Hu, X Peng, Q Xu, Q Wang, H Li. The production mechanism and immunosuppression effect of pulmonary surfactant protein D via toll like receptor 4 signaling pathway in human corneal epithelial cells during Aspergillus fumigatus infection. International immunopharmacology 2015, 29 (2), 433-439
  • N Jiang, L Zhang, G Zhao, J Lin, Q Wang, Q Xu, C Li, L Hu, X Peng, F Yu. Indoleamine 2, 3-dioxygenase regulates macrophage recruitment, polarization and phagocytosis in Aspergillus fumigatus keratitis. Investigative Ophthalmology & Visual Science 2020, 61 (8), 28-28.
  • Q Sun, C Li, J Lin, X Peng, Q Wang, N Jiang, Q Xu, G Zhao. Celastrol ameliorates Aspergillus fumigatus keratitis via inhibiting LOX-1. International immunopharmacology 2019, 70, 101-109.
  • X Peng, SA Ekanayaka, SA McClellan, RP Barrett, K Vistisen, LD Hazlett. Characterization of Three Ocular Clinical Isolates of P. aeruginosa: Viability, Biofilm Formation, Adherence, Infectivity, and Effects of Glycyrrhizin. Pathogens 2017, 6 (4), 52.
  • L Zhan, X Peng, J Lin, Y Zhang, H Gao, Y Zhu, Y Huan, G Zhao. Honokiol reduces fungal load, toll-like receptor-2, and inflammatory cytokines in Aspergillus fumigatus keratitis. Investigative Ophthalmology & Visual Science 2020, 61 (4), 48-48.
  • C Li, C Li, J Lin, G Zhao, Q Xu, N Jiang, Q Wang, X Peng, G Zhu, J Jiang. The role of autophagy in the innate immune response to fungal keratitis caused by Aspergillus fumigatus infection. Investigative Ophthalmology & Visual Science 2020, 61 (2), 25-25.
  • JQ Jiang, C Li, CX Cui, YN Ma, GQ Zhao, XD Peng, Q Xu, Q Wang. Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis. International Journal of Ophthalmology 2019, 12 (6), 898.
  • X Peng, G Zhao, J Lin, C Li. Interaction of mannose binding lectin and other pattern recognition receptors in human corneal epithelial cells during Aspergillus fumigatus infection. International Immunopharmacology 2018, 63, 161-169.
  • Y Zhu, X Peng, Y Zhang, J Lin, G Zhao. Baicalein protects against aspergillus fumigatus keratitis by reducing fungal load and inhibiting TSLP-induced inflammatory response. Investigative Ophthalmology & Visual Science 2021, 62 (6), 26-26.
  • SA Ekanayaka, SA McClellan, X Peng, RP Barrett, R Francis, LD Hazlett. HMGB1 Antagonist, Box A, Reduces TLR4, RAGE, and Inflammatory Cytokines in the Cornea of P. aeruginosa-Infected Mice. Journal of Ocular Pharmacology and Therapeutics 2018, 34 (10), 659-669.
  • Y Zhou, J Lin, X Peng, C Li, J Zhang, Q Wang, G Zhu, J You, G Zhao. The role of netrin-1 in the mouse cornea during Aspergillus fumigatus infection. International Immunopharmacology 2019, 71, 372-381.
  • M Yin, C Li, XD Peng, GQ Zhao, Y Wu, HR Zheng, Q Wang, Q Xu, N Jiang. Expression and role of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis. International Journal of Ophthalmology 2019, 12 (5), 697.
  • X Tian, X Peng, J Lin, Y Zhang, L Zhan, J Yin, R Zhang, G Zhao. Isorhamnetin ameliorates Aspergillus fumigatus keratitis by reducing fungal load, inhibiting pattern-recognition receptors and inflammatory cytokines. Investigative Ophthalmology & Visual Science 2021, 62 (3), 38-38.
  • G Zhu, G Zhao, J Lin, C Li, Q Wang, Q Xu, X Peng, H Zheng. FCN-A mediates the inflammatory response and the macrophage polarization in Aspergillus fumigatus keratitis of mice by activating the MAPK signaling pathway. International Immunopharmacology 2020, 83, 106473.
  • N Jiang, GQ Zhao, J Lin, LT Hu, CY Che, C Li, Q Wang, Q Xu, J Zhang, XD Peng. Expression of indoleamine 2, 3-dioxygenase in a murine model of Aspergillus fumigatus keratitis. International Journal of Ophthalmology 2016, 9 (4), 491.
  • J Yin, X Peng, J Lin, Y Zhang, J Zhang, H Gao, X Tian, R Zhang, G Zhao. Quercetin ameliorates Aspergillus fumigatus keratitis by inhibiting fungal growth, toll-like receptors and inflammatory cytokines. International Immunopharmacology 2021, 93, 107435.
  • X Peng, G Zhao, J Lin, J Qu, Y Zhang, C Li. Phospholipase Cγ2 is critical for Ca 2+ flux and cytokine production in anti-fungal innate immunity of human corneal epithelial cells. BMC ophthalmology 2018,18 (1), 1-8.
  • S Liu, J Yang, X Peng, J Li, C Zhu. The natural product fucoidan inhibits proliferation and induces apoptosis of human ovarian cancer cells: Focus on the pi3k/akt signaling pathway. Cancer Management and Research 2020, 12, 6195.
  • GR Yu, J Lin, J Zhang, CY Che, XD Peng, C Li, LT Hu, GQ Zhu, K He. Mincle in the innate immune response of mice fungal keratitis. International Journal of Ophthalmology 2018, 11 (4), 539.
  • CY Li, C Li, H Li, GQ Zhao, J Lin, Q Wang, XD Peng, Q Xu, GQ Zhu. Disparate expression of autophagy in corneas of C57BL/6 mice and BALB/c mice after Aspergillus fumigatus infection. International Journal of Ophthalmology 2019, 12 (5), 705.
  • X Peng, SA Ekanayaka, SA McClellan, RP Barrett, K Vistisen, LD Hazlett. Effects of glycyrrhizin on a drug resistant isolate of Pseudomonas aeruginosa. EC Ophthalmol 2018, 9, 265-280.
  • Y Huan, XD Peng, J Lin, YX Zhang, L Zhan, H Gao, GQ Zhao. Anti-inflammatory effects of astaxanthin against fungal keratitis. International Journal of Ophthalmology 2020, 13 (11), 1681.
  • C Li, YY Liu, GQ Zhao, J Lin, CY Che, N Jiang, N Li, J Zhang, K He, XD Peng. Role of vasoactive intestinal peptide in Aspergillus fumigatus-infected cornea. International Journal of Ophthalmology 2018, 11 (2), 183.
  • L Cong, YP Xia, GQ Zhao, J Lin, Q Xu, LT Hu, JQ Qu, XD Peng. Expression of vitamin D receptor and cathelicidin in human corneal epithelium cells during fusarium solani infection. International Journal of Ophthalmology 2015, 8 (5), 866.
  • Y Niu, C Ren, X Peng, C Li, Q Xu, L Hu, Z Zhang, G Zhao, J Lin. IL-36α Exerts Proinflammatory Effects in Aspergillus fumigatus Keratitis of Mice Through the Pathway of IL-36α/IL-36R/NF-κB. Investigative Ophthalmology & Visual Science 2021, 62 (4), 16-16.
  • X Liu, J You, X Peng, Q Wang, C Li, N Jiang, C Che, Y Zhou, H Zheng. Mammalian Ste20-like kinase 4 inhibits the inflammatory response in Aspergillus fumigatus keratitis. International Immunopharmacology 2020, 88, 107021.
  • NJ Carruthers, SA McClellan, M Somayajulu, A Pitchaikannu, D Bessert, XD Peng. Effects of Glycyrrhizin on Multi-Drug Resistant Pseudomonas aeruginosa. Pathogens 2020, 9 (9), 766.
  • J You, J Lin, YF Zhou, XD Peng, H He, C Li, GQ Zhu, XQ Zhao, GQ Zhao. Role of the IL-33/ST2/p38 signaling pathway in the immune response of corneal epithelial cells to Aspergillus fumigatus infection. International journal of ophthalmology 2019, 12 (4), 549.
  • GQ Zhu, GQ Zhao, C Li, J Lin, N Jiang, Q Wang, Q Xu, XD Peng. Regulation of LOX-1 on adhesion molecules and neutrophil infiltration in mouse Aspergillus fumigatus keratitis. International Journal of Ophthalmology 2020, 13 (6), 870.
  • L Zhang, N Jiang, GQ Zhao, XD Peng, GQ Zhu, W Jiang, JJ Ma. Expression and role of aryl hydrocarbon receptor in Aspergillus fumigatus keratitis. International Journal of Ophthalmology 2020, 13 (2), 199.
  • X Liu, J Sui, C Li, X Peng, Q Wang, N Jiang, Q Xu, L Wang, J Lin, G Zhao. Preparation of a Nanobody Specific to Dectin 1 and Its Anti-inflammatory Effects on Fungal Keratitis. International Journal of Nanomedicine 2022, 17, 537.
  • Y Niu, J Lin, C Li, X Peng, N Jiang, Q Xu, M Yin, H Lin, L Gu, G Zhao. Galectin-3 plays an important pro-inflammatory role in A. fumigatus keratitis by recruiting neutrophils and activating p38 in neutrophils. International Immunopharmacology 2021, 97, 107706.
  • X Zhu, X Peng, J Lin, Y Zhang, H He, G Zhao. Lipoxin A4 activates ALX/FPR2 to attenuate inflammation in Aspergillus fumigatus keratitis. International Immunopharmacology 2021, 96, 107785.
  • J Luan, X Peng, J Lin, Y Zhang, X Tian, L Zhan, G Zhao. The therapeutic potential of chondroitin sulfate in Aspergillus fumigatus keratitis. Molecular Immunology 2022, 147, 50-61.
  • M Wang, B Wang, W Song, X Wang, X Peng, X Long, Y Xia. Oxygen Reduction Activity of B← N‐Containing Organic Molecule Affected by Asymmetric Regulation. Small 2022, 18 (3), 2105524.
  • H Gao, X Peng, L Zhan, J Lin, Y Zhang, Y Huan, G Zhao. The role of Glabridin in antifungal and anti-inflammation effects in Aspergillus fumigatus keratitis. Experimental Eye Research 2022, 214, 108883.
  • X Huang, X Liu, X Peng, C Li, J Sui, H Lin, J Lin, G Zhao. Production of egg yolk antibody against A. fumigatus and its therapeutic potential for treating A. fumigatus keratitis. Microbial Pathogenesis 2021, 158, 105081.
  • R Zhang, X Peng, J Lin, Y Zhang, L Zhan, X Tian, J Yin, G Zhao. The Role of SREC-Ⅰ in Innate Immunity to Aspergillus fumigatus Keratitis. Investigative Ophthalmology & Visual Science 2021, 62 (9), 12-12.
  • HJ Yan, N Jiang, LT Hu, Q Xu, XD Peng, H Yang, WY Zhao, LY Lyu. CD23 mediated the induction of pro-inflammatory cytokines Interleukin-1 beta and tumor necrosis factors-alpha in Aspergillus fumigatus keratitis. Chinese Medical Journal 2021, 134 (08), 1001-1003.
  • M He, J You, X Liu, X Peng, C Li, S Yang, Q Xu, J Lin, G Zhao. Perillaldehyde Protects Against Aspergillus fumigatus Keratitis by Reducing Fungal Load and Inhibiting Inflammatory Cytokines and LOX-1. Current Eye Research, 2022, 1-8.
  • X Ji, X Peng, X Long, Y Zhang, J Lin, J Yin, R Zhang, G Zhao. Laccase-mediated functionalization of natamycin by gallic acids for the therapeutic effect on Aspergillus fumigatus keratitis. European Journal of Pharmacology, 2022, 175041.
  • X Tian, X Peng, X Long, J Lin, Y Zhang, L Zhan, G Zhao. Oxidized chondroitin sulfate eye drops ameliorate the prognosis of fungal keratitis with anti-inflammatory and antifungal effects. Journal of Materials Chemistry B, 2022.
  • Q Xu, Q Wang, LT Hu, J Lin, N Jiang, XD Peng, C Li, GQ Zhao. NADPH oxidase 2 plays a protective role in experimental Aspergillus fumigatus keratitis in mice through killing fungi and limiting the degree of inflammation. International Journal of Ophthalmology 2022, 15 (7), 1044.
  • S Ma, H Lin, X Peng, C Li, Q Wang, Q Xu, M He, D Shao, X Liu, G Zhao. Hinokitiol alters Gene Expression in Aspergillus fumigatus, protects against fungal keratitis by Reducing Fungal Load, LOX-1, Proinflammatory cytokines and Neutrophil Infiltration. BioRxiv, 2022.
  • CJ Ren, YF Zhou, Y Wu, XD Peng, C Li, Q Wang, GQ Zhu, J You, J Zhang. Changes in corneal innervation and pain responses in fungal keratitis. International Journal of Ophthalmology 2022, 13 (1), 1.
  • Y Huan, X Peng. Anti-Inflammatory Effects of Astaxanthin against Fungal Keratitis Induced by Aspergillus Fumigatus. Advances in Clinical Medicine, 2020, 10(3), 378-388.
  • G Zhao, J Lin, C Li, X Peng, Q Wang. Inhibition of Autophagy Aggravates Fungal Keratitis Caused by Aspergillus Fumigatus. Investigative Ophthalmology & Visual Science 2020, 60 (9), 2552-2552.
  • X Peng, SA Ekanayaka, SA McClellan, A Eby, L Hazlett. Characterization of ocular clinical isolates and non-ocular multi-drug resistant strains of Pseudomonas aeruginosa and their susceptibility to killing by glycyrrhizin. Investigative Ophthalmology & Visual Science 2019, 58 (8), 5762-5762.
  • L Cong, G Zhao, J Lin, L Hu, Q Xu, Y Xia, J Qu, X Peng. Retrospective Analysis of 385 Patients Received Penetrating Keratoplasty. Hans Journal of Ophthalmology, 2014, 3, 29-34.

Honors 

  • “Dr. Raniyah Ramadan Young Investigator Award in Microbiology” by ARVO in 2017.
  • “Excellent Student Scholarships” by Qingdao University in 2017.
  • “Excellent Students’ leader” by Qingdao University in 2013.

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