Articles

Feb 14, 2024

Presumed Low Dose Dapsone Induced Methemoglobinemia

Methemoglobinemia is one of the rare but fatal causes of cyanosis in which hemoglobin gets oxidized changing its Ferrous (Fe2+) state to a ferric state (Fe3+) and so methemoglobin is unable to bind oxygen and deliver it to tissues despite the adequate concentration of oxygen in the blood. Causes can be congenital or acquired; the acquired causes include exposure to different chemicals like benzocaine, dapsone, herbicides, pesticides, nitrobenzene, aniline, and fumes from combustion engines.