Articles

Feb 03, 2023

Evaluation of 2,3-Disubstituted Quinazolones for their Antimicrobial Study by the Standardized Procedures as Recommended by the National Committee for Clinical Laboratory Standards (NCCLS)

Heating under reflux a mixture of anthranilic acid and benzoyl chloride in dry pyridine afforded 2-phenyl-4H-benzo [d] [1,3] oxazine-4-one(1). Reaction of (1) with an excess equivalent of hydrazine hydrate in dry pyridine solvent furnished 3-amino-2-phenylquinazolin-4(3H)-one(2) which on reaction with carbamide in ethanol containing catalytic quantity of HCl yielded 1-(4-oxo-2-phenylquinazolin-3(4H)-one)(3). Interaction of (3) with arylamido/imidoalcanolsin conc. H2SO4 generated targets compoun...